Project Summary:

Malaria affects more than half of the world’s population, but its impact extends beyond the blood. In particular, Plasmodium falciparum infection increases susceptibility to secondary bacterial infections, such as invasive non-Typhoidal Salmonella, which can lead to sepsis—a major cause of child mortality worldwide. How malaria reshapes intestinal health to create this vulnerability remains poorly understood. 

Our work explores the intestine as a critical site of malaria pathology. Using rodent models, we have shown that malaria induces intestinal inflammation, disrupts the epithelial barrier, and promotes bacterial colonization, creating a “leaky gut.” These changes correlate with biomarkers of intestinal inflammation and altered gut motility, suggesting broader impacts on nutrient absorption and microbiome composition. 

The project aims to uncover the cellular and molecular mechanisms driving malaria-induced intestinal inflammation. Findings from this research will improve our understanding of malaria-associated gastroenteritis and may reveal strategies to reduce secondary infections, ultimately enhancing intestinal resilience and reducing reliance on antibiotics.